2025 | Breast Cancer Screening
Quantitative Transmission Imaging Compared With MRI As Supplemental Screening For High Lifetime Risk Of Breast Cancer (QTIE Study)
Tiffany Sae-Kho, Christine Lee, Chidi Nwachukwu
Mayo Clinic Clinical Trial 24-008575
Mayo Clinic, Rochester, Minnesota
April 10, 2025 | Ultrasonic Imaging and Tomography
Toward data sparsification for 3D reflection imaging in QTI Breast Acoustic CT™ scanners
Linh Nguyen, James Wiskin, Bilal Malik
SPIE Medical Imaging 2025
Proceedings Volume 13412, Medical Imaging 2025: Ultrasonic Imaging and Tomography; 134120W (2025)
https://doi.org/10.1117/12.3047434
April 10, 2025 | A Brief Mathematical Demonstration
Exact Kramers-Kronig relation and its applications (Conference Presentation)
James W. Wiskin
SPIE Medical Imaging 2025
Proceedings Volume Medical Imaging 2025: Ultrasonic Imaging and Tomography, 134120E
https://doi.org/10.1117/12.3046826
April 10, 2025 | Feasibility of Transcranial Acoustic Propagation in Neonates
Transcranial imaging with 3D ultrasound tomography: proof of concept
James Wiskin, Bilal Malik, John Klock
SPIE Medical Imaging 2025
Proceedings Volume Medical Imaging 2025: Ultrasonic Imaging and Tomography, 134120U (2025)
https://doi.org/10.1117/12.3046804
April 10, 2025 | QTI Breast Acoustic CT™ (BACT)
Quantitative analysis of the computational complexity and data information content of 3D ultrasound BACT versus magnetic resonance imaging
James Wiskin, Bilal Malik, John Klock
SPIE Medical Imaging 2025
Proceedings Volume Medical Imaging 2025: Ultrasonic Imaging and Tomography, 134120R (2025)
https://doi.org/10.1117/12.3046831
March 10, 2025 | Mammary Ultrasonography
Angular spatial compounding of diffraction corrected images improves ultrasound attenuation measurements
Mingrui Liu, James Wiskin, Gregory J Czarnota, Michael L Oelze,
DOI: 10.1121/10.0036124
The Journal of the Acoustical Society of America
March 15, 2019
Correlation of ultrasound tomography to MRI and pathology for the detection of prostate cancer
Reza Seifabadi, Alexis Cheng, Bilal Malik, Shun Kishimoto, James Wiskin, Jeeva Munasinghe, Ayele Negussie, Ivane Bakhutashvili, Murali Krishna, Peter Choyke, Peter Pinto, Arman Rahmim, Emad Boctor, Maria Merino, Mark Lenox, Baris Turkbey, Bradford Wood
Proceedings Volume 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography; 109550C (2019)
CorrelationProstateMRI
March 1, 2019
Full wave 3D inverse scattering: 21st century technology for whole body imaging
J. Wiskin, B. Malik, R. Natesan, N. Pirshafiey, M. Lenox, and J. Klock, “Full wave 3D inverse scattering: 21st century technology for whole body imaging,” The Journal of the Acoustical Society of America, vol. 145, pp. 1857-1857, 2019.
February 19, 2019 | SPIE
Radiologic-pathologic Validation of Transmission Ultrasound Tomography Using Microscopy with UV Surface Excitation
Bilal Malik1, Austin Todd2, Alyson Terry1, Farzad Fereidouni2, Rajni Natesan1, John Klock1, James Wiskin1, Mark Lenox1, Richard Levenson2
1. QT Ultrasound Labs, Novato, CA
2. Department of Pathology and Lab Medicine, UC Davis, Sacramento, CA
This study proves that full 3D transmission ultrasound has a remarkable ability in identification of breast anatomical structures. Multimodality comparison also shows that transmission ultrasound tomography can be useful in understanding breast anatomy and physiology.
February 17, 2019 | SPIE
Transmission Ultrasound Imaging of the Human Knee
James W. Wiskin, Bilal Malik, Rajni Natesan, Nasser Pirshafiey, John Klock, and Mark Lenox “3D full inverse scattering ultrasound tomography of the human knee (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 109550K (15 March 2019); doi: 10.1117/12.2512595
In this study of full wave 3D ultrasound tomography of the knee, we found:
Even in the presence of bone, full 3D inverse scattering transmission ultrasound gives quantitative estimates of tissue characteristics
– Tendons, ligaments, cartilage, muscle, fat
– Acoustic energy interacts with tissue at super-molecular level, giving tissue characteristics unavailable with other modalities
– Periosteum, cortical thickness
Even in presence of bone, fused transmission and reflection images
– Speckle free –refraction corrected/compounded over 360 degrees
– High resolution
– Consistent over time
June 30, 2018 | eBook: Emerging Trends in Ultrasound
Transmission Ultrasound Imaging Using 3D Inverse Scattering
John C. Klock, Mark W Lenox, Bilal H. Malik, Rajni Natesan
Full 3D inverse scattering ultrasound tomography is a novel method unused by others in medical imaging. The technology has a unique mechanical architecture capable of acquiring speed of sound and reflection images in 3D. The image reconstruction is computationally challenging and involves solving complex equations using high-performance computing. Laboratory studies demonstrate that the technique has high resolution and high contrast-to-noise ratios in both speed and reflection images. Clinical studies show that this technology is capable of visualizing breast microanatomy and breast microcalcifications along with providing a method for tissue classification using biomarkers. Finally, the technology has improved performance for imaging dense breasts. Full 3D inverse scattering ultrasound tomography offers unparalleled imaging of the breast including microanatomic features of the breast.
March 29, 2018 | AAPM Medical Physics
Quantitative transmission ultrasound tomography: Imaging and performance characteristics
Bilal Malik, Robin Terry, James Wiskin, Mark Lenox
Quantitative Transmission (QT) ultrasound has shown promise as a breast imaging modality. This study characterizes the performance of the latest generation of QT ultrasound scanners: QTScanner 2000. The results show an improvement in the imaging performance of the system in comparison to earlier ultrasound tomography systems, which are applicable to clinical applications of the system, such as breast imaging.
March 27, 2018 | Academic Radiology
Breast Cyst Fluid Analysis Correlations with Speed of Sound Using Transmission Ultrasound
Bilal H. Malik, PhD, John C. Klock, MD
The speed of sound of breast macrocysts, as observed using transmission ultrasound, correlated with the cytological features of intracystic cell clumps. On the basis of this work with speed as a classifier, we propose a spectrum of breast macrocysts from fluid-filled to highly cellular. Our results suggest high-speed cysts are mature macrocysts with high cell counts and many cellular clumps that correlate with cyst microanatomy as seen by transmission ultrasound.
August 8, 2017 | BAOJ Clinical Trials
Visual Grading Assessment of Quantitative Transmission Ultrasound Compared to Digital X-ray Mammography and Hand-held Ultrasound in Identifying Ten Breast Anatomical Structures
John C. Klock, Elaine Iuanow, Kathleen Smith, and Nancy A. Obuchowski
We performed visual grading analysis studies comparing transmission ultrasound, digital x-ray mammography and hand-held ultrasound when visualizing ten normal breast anatomic structures. To compare the image quality of the three modalities, multiple readers scored the image quality of transmission ultrasound compared to the other two modalities using an ordinal rating scale. The study showed that transmission ultrasound can adequately see all the major anatomical features of the human breast, including ductal and glandular tissue detail, even in dense breasts.
May 23, 2017 | IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
3D Nonlinear Acoustic Inverse Scattering: Algorithm and Quantitative Results
James Wiskin, David Borup, Elaine Iuanow, John C. Klock, Mark Lenox
In this paper, we describe the technical details of our image reconstruction algorithm. We show that the 3D inversion algorithm provides a more detailed image when compared to 2D algorithms, which results in a clearer depiction of the breast anatomy and lesions.
May 23, 2017 | Academic Radiology
Accuracy of Cyst vs. Solid Diagnosis in the Breast Using Quantitative Transmission (QT) Ultrasound
Elaine Iuanow, Kathleen Smith, Nancy A. Obuchowski, Jennifer Bullen, John C. Glock
This study shows the ability of QT ultrasound to determine whether a breast lesion is a cyst or a solid. QT ultrasound imaging was performed as adjunct to mammography. A total of fourteen readers evaluated the images. The results show that QT ultrasound provides an accurate assessment of a cyst versus a solid lesion in the breast.
May 2, 2017
Quantitative 3D high resolution transmission ultrasound tomography: creating clinically relevant images (Conference Presentation)
James Wiskin, John Klock, Elaine Iuanow, Dave Borup, Robin Terry, Bilal Malik, Mark Lenox
Proceedings Volume 10139, Medical Imaging 2017: Ultrasonic Imaging and Tomography; 101390Y (2017)
December 9, 2016 | Scientific Reports
Objective Breast Tissue Image Classification Using Quantitative Transmission Ultrasound Tomography
Bilal Malik, John C. Klock, James Wiskin, and Mark Lenox
We show that QT ultrasound is essentially a multi-modality imaging system that can differentiate between different breast tissue types such as skin, fat, glands, ducts and connective tissue. This study is a first step towards a computer aided detection/diagnosis platform for QT ultrasound.
September 5, 2016 | The International Journal of Biomedical Imaging
Anatomy-Correlated Breast Imaging and Visual Grading Analysis Using Quantitative Transmission Ultrasound
John C. Klock, Elaine Iuanow, Bilal Malik, Nancy A. Obuchowski, James Wiskin, and Mark Lenox
Breast imaging performed using QT ultrasound can delineate anatomical structures within the breast. For many breast features such as skin, connective tissue, blood vessels and ductal units, QT ultrasound shows significantly better image quality in comparison to mammography.
October 8, 2015 | The International Journal of Biomedical Imaging
Imaging Performance of Quantitative Transmission Ultrasound
Mark Lenox, James Wiskin, Matthew A. Lewis, Stephen Darrouzet, David Borup, and Scott Hsieh
We provide a metrics to characterize transmission ultrasound. We then use this metrics to measure the imaging performance of QT ultrasound. We evaluated a prototype QT scanner for its ability to perform both speed of sound and reflection imaging.
April 1, 2014
Quantitative three dimensional nonlinear inverse scattering and reflection breast imaging: Initial clinical results
J. Wiskin, D. Borup, E. Iuanow, J. Klock, and M. Lenox, “Quantitative three dimensional nonlinear inverse scattering and reflection breast imaging: Initial clinical results,” The Journal of the Acoustical Society of America, vol. 135, pp. 2155-2155, 2014.
August 28, 2012
Quantitative volumetric breast imaging with 3D inverse scatter computed tomography
M. Andre, J. Wiskin, D. Borup, S. Johnson, H. Ojeda-Fournier, and L. Olson, “Quantitative volumetric breast imaging with 3D inverse scatter computed tomography,” Conf Proc IEEE Eng Med Biol Soc, vol. 2012, pp. 1110-3, 2012
March 12, 2010
Inverse scattering and refraction corrected reflection for breast cancer imaging
J. Wiskin, D. Borup, S. Johnson, M. Berggren, D. Robinson, J. Smith, J. Chen, Y. Parisky, John Klock
Proceedings Volume 7629, Medical Imaging 2010: Ultrasonic Imaging, Tomography, and Therapy; 76290K (2010)
InverseScattering Paper
1976 - 2019
Archive of Transmission Ultrasound Research Papers
1. J. F. Greenleaf, S. A. Johnson, S. L. Lee, G. T. Hermant, and E. H. Woo, “Algebraic Reconstruction of Spatial Distributions of Acoustic Absorption within Tissue from Their Two-Dimensional Acoustic Projections,” in Acoustical Holography: Volume 5, P. S. Green, Ed., ed Boston, MA: Springer US, 1974, pp. 591-603.
2. Wiskin, J. W., “Modelling of Acetylcholine Release from Neurons and Parameter Estimation”,Lect. in Applied Math, Vol. 19, American Math. Soc. , 1980.
3. S. A. Johnson, F. Stenger, C. Wilcox, J. Ball, and M. J. Berggren, “Wave Equations and Inverse Solutions for Soft Tissue,” in Acoustical Imaging, J. P. Powers, Ed., ed Boston, MA: Springer US, 1982, pp. 409-424.
4. S. A. Johnson and M. L. Tracy, “Inverse Scattering Solutions by a Sinc Basis, Multiple Source, Moment Method — Part I: Theory,” Ultrasonic Imaging, vol. 5, pp. 361-375, 1983.
5. S. A. Johnson, Y. Tae-Hoon, and R. Jung-Woong. (1983, Inverse scattering solutions of scalar Helmholtz wave equation by a multiple source moment method. Electronics Letters 19(4), 130-132. Available: http://digital-library.theiet.org/content/journals/10.1049/el_19830092
6. M. L. Tracy and S. A. Johnson, “Inverse scattering solutions by a sinc basis, multiple source, moment method — part II: Numerical evaluations,” Ultrasonic Imaging, vol. 5, pp. 376-392, 1983/10/01/ 1983.
7. S. A. Johnson, Y. Zhou, M. K. Tracy, M. J. Berggren, and F. Stenger, “Inverse scattering solutions by a sinc basis, multiple source, moment method — Part III: Fast algorithms,” Ultrasonic Imaging, vol. 6, pp. 103-116, 1984/01/01/ 1984.
8. Johnson, S.A., D.T. Borup, Wiskin, J. W., R.S. Eidens and M.J. Berggren, , “Imaging Shear and Bulk Elastic parameters in Three-Dimensions by fullwave, Non-Pertubative Inverse Scattering Tomography with Examples from Large Grids, Limited View Angles and Real Data,” Acoustic Imaging 18, 1989.
9. Wiskin, J. W., S.A. Johnson, D.T. Borup and M.J. Berggren, , “Non-pertubative Modeling and Inversion of Elastic and Acoustic inhomogeneous Structures Imbedded within a Layered Half Space,” SEG 1989 Summer Workshop, Snowbird, UT, Aug. 13–17, 1989.
10. Borup D. , S. Johnson, Wiskin, J. W. and M. Berggren, 1989, “Integral equation algorithms for imaging arbitrarily inhomogeneous distributions of elastic parameters imbedded in a homogeneous space,” SEG 1989 Summer Workshop, Snowbird, UT, Aug. 13–17, 1989.
11. Seader, J.D., M. Kuno, W.J. Lin, Johnson, S. A. K. Unsworth and Wiskin, J., W., “Homotopy Continuation methods“, Computers and Chemical Engineering..Vol. 14, No. 1, pp. 71-85, 1990 — Winner Best Paper of 1990 Award.
12. Wiskin, J. W., “Geometric and Integral Equation Methods for Scattering in Layered Media”., Ph.D. Dissert., Dept. Math., University Microfilms International, Ann Arbor, MI., 1991.
13. Johnson, S. A., D. T. Borup, M J. Berggren, Wiskin, J. W., and R. S. Eidens, “Modeling of inverse scattering and other tomographic algorithms in conjunction with wide bandwidth acoustic transducer arrays for towed or autonomous sub-bottom imaging systems,” Proc. of Mastering the Oceans through Technology (Oceans 92) , Newport. R.I. Oct. 26-29, 1992, pp 294-299, 1992
14. S. A. Johnson, D. T. Borup, M. J. Berggren, J. W. Wiskin, R. Eidens, “Modeling of Inverse Scattering and Other Tomographic Algorithms in Conjuction with Wide Bandwidth Acoustic Transducer Arrays for Towed or Autonomous Sub-bottom Imaging Systems”, IEEE Oceans 92. Conference, Vol 1, pp. 294-299 (Oct 26-29, 1992).
15. S.A. Johnson, M.J. Berggren, D.T. Borup, J.W. Wiskin, R.S. Eidens, and H. Leng, “Comparison of Inverse Scattering and Other Tomographic Imaging Algorithms Using Simulated and Tank Data for Modeling Subbottom Imaging Systems,” IEEE Oceans ’93 Conference, October 18- 21, 1993 , Vol. I, pp. 458-492 (1993).
16. J.W. Wiskin, S.A. Johnson, D.T. Borup, M. Berggren, R. Eidens, Y. Zhang. “Full Inverse Scattering vs. Born-Like Approximation for Imaging in a Stratified Ocean”, IEEE Oceans ’93 Conference, Vol. III, pp. 450-455 (October 18-21, 1993).
17. Wiskin, J. W., S. A. Johnson, D. Borup, M. Berggren, and R. Eidens, “Full Inverse Scattering vs. Born-like Approximation for Imaging in a Stratified Ocean”, Proc. of Engineering in harmony with the Ocean (Oceans ’93), Victoria, British Columbia, Oct. 1993.
18. Johnson, S. A., D. T. Borup, M. J. Berggren, Wiskin, J. W., R. S. Eidens, 1993, “Comparison of Inverse Scattering and Other Tomographic Imaging Algorithms using simulated and Tank Data for Modeling Sub-bottom Imaging Systems,” Proc. of Engineering in harmony with the Ocean (Oceans ’93), Victoria, British Columbia, Oct. 1993.
19. Wiskin, J.W., D. T. Borup, and S. A. Johnson, “Inverse Scattering from cylinders of arbitrary cross-section in Stratified Environments”, in Progress in Electromagnetics Research Symposium (PIERS), , p.195. July 24-28, University of Washington, Seattle, WA, 1995
20. Borup, D. T., S. A. Johnson, and J. W. Wiskin, FDTD and Integral Equation simulation of a Prototype Ultrasound Breast Scanner, in Progress in Electromagnetics Research Symposium, (PIERS) , p. 621, July 24-28, University of Washington, Seattle, WA, 1995
21. R.S. Eidens, J.W. Wiskin, D.T. Borup, S.A. Johnson, and M.J. Berggren, “Experimental Verification of Acoustic Inverse Scattering Tomography — Simple Phantoms,” submitted to IEEE UFFC.
22. Wiskin, J.W., D. T. Borup, and S. A. Johnson, “Inverse Scattering from cylinders of arbitrary cross-section in Stratified Environments”, in Progress in Electromagnetics Research Symposium (PIERS), July 24-28, 1995, University of Washington, Seattle, WA, p.195.
23. Borup, D. T., S. A. Johnson, and J. W. Wiskin, FDTD and Integral Equation simulation of a Prototype Ultrasound Breast Scanner, in Progress in Electromagnetics Research Symposium, (PIERS) July 24-28, 1995, University of Washington, Seattle, WA, pp. 621.
24. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael J. Berggren, Michael S. Zhdanov, Kyle Bunch, and Richard Eidens, “Application of Inverse Scattering and Other Refraction Corrected methods to Environmental Imaging with Acoustic or Electromagnetic Energy”, in Next Generation Environmental models and computational methods., Ed. George Delic, Mary F. Wheeler, Proceedings of a U.S. Environmental Protection Agency sponsored workshop at the National Environmental Supercomputing Center. 1997 SIAM, pp 295-312. Libr. Congress Card No. 96-71103, ISBN 0-89871-378-1
25. Yuan, X. , J. W. Wiskin, D. T. Borup, M. Berggren, Rick Eidens, S. A. Johnson, “Formulation and Validation of Berenger’s PML Absorbing Boundary for the FDTD simulation of Acoustic Scattering”, IEEE Trans. UFFC. 44, 4, 1997 (IEEE Trans Ultrason., Ferro, Freq. Control..
26. Yuan, X., D. Borup D. T., Wiskin, J. W., Berggren, M., Johnson, S. A. and R. Eidens, “Simulation of acoustic wave propagation in dispersive media with relaxation losses by using FDTD methods with PML absorbing boundary condition”, accepted for publication, Trans. of Ultrasonics, Ferro., and Freq. Control.
27. J.W. Wiskin, D.T. Borup, and S.A. Johnson. “Inverse Scattering from cylinders of arbitrary cross-section in stratified environments via Green’s operator,” J. Acoust. Soc. Am., 102 (2), Pt.1, August, pp. 853-864, 1997..
28. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael J. Berggren, Michael S. Zhdanov, Kyle Bunch, and Richard Eidens, “Application of Inverse Scattering and Other Refraction Corrected methods to Environmental Imaging with Acoustic or Electromagnetic Energy“, in Next Generation Environmental models and computational methods., Ed. George Delic, Mary F. Wheeler, Proceedings of a U.S. Environmental Protection Agency sponsored workshop at the National Environmental Supercomputing Center, S.I.A.M., 1997.
29. Wiskin, J. W., Borup, D. T., Johnson, S. A., “Inverse Scattering from cylinders of arbitrary cross-section in stratified environments via Green’s operator“, J. Acoust. Soc. America, 102 (2), Pt.1, August, pp. 853-864, 1997.
30. Yuan, X. ,Wiskin, J. W., D. T. Borup, M. Berggren, Rick Eidens, S. A. Johnson, “Formulation and Validation of Berenger’s PML Absorbing Boundary for the FDTD simulation of Acoustic Scattering”, IEEE Trans. UFFC. 44, 4, (IEEE Trans Ultrason., Ferro, Freq. Control.), 1997.
31. Wiskin, J. W, “Fast and accurate 3D acoustic propagation and inversion in layered media environments”, Canadian Acoustical Association Annual meeting, London, Ontario, Canada, and published in special issue of Canadian Acoustics/Acoustique Canadienne, Vol. 26, no. 3, September 1998, proceedings, cahiers des actes, Oct. 27-30, 1998.
32. J.W. Wiskin, D. Borup, S.A. Johnson. “Fast and Accurate Acoustic Propagation and Inversion in Layered Media Environments,” presented Oct. 27-30, 1998, at the Canadian Acoustic Association (CAA) Conference, in London, Ontario, Canada, Secretary of CAA, Ottawa, Ontario, Canada.
33. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael Zhdanov, Edward Nichols and Ugo Conti, and Giuseppe Guarino. “Construction of CPT Hardware and Software for 3-D, EM Imaging of DNAPL by Quasi-Static Regime Methods,” 2nd Quadrennial Symposium on Three-Dimensional Electromagnetics (Symposium Honoring G Hohmann), Univ. of Utah, Oct. 26-29, 1999.
34. (ABSTRACT FOR INVITED TALK) S.A. Johnson, D.T. Borup, J.W. Wiskin: “Integrating Experimental Procedures with Algorithms for Practical Imaging by Full Wave, Nonlinear Inverse Scattering”. XXVIth General Assemble of International Union of Radio Science (U.S.R.I.). , Assemblee’ Ge’ne’rale de l’Union radio-scientifique internationale . Toronto, Ontario, Canada, August 13-21, 1999. Invited Lecture.
35. Wiskin, JW, Johnson, SA, Borup, DT., “Integrating Experimental Procedures with Algorithms for Practical Imaging by Full Wave, Non-Linear Inverse Scattering,” Invited Lecture (Presenting Author: J. Wiskin), Assemblee ’ Generale de l’Union radio-scientifique internationale, XXVIth General Assembly of the International Union of Radio Science (U.R.S.I.), Aug. 13-21, Toronto, Ontario, Canada, 1999.
36. Yuan, X., D. Borup D. T., Wiskin, J. W., Berggren, M., Johnson, S. A. and R. Eidens, “Simulation of acoustic wave propagation in dispersive media with relaxation losses by using FDTD methods with PML absorbing boundary condition“, I.E.E.E. Trans. of Ultrasonics, Ferro., and Freq. Control., Vol 46, No. 1, January, 1999.
37. Wiskin, J.W., M. Zhdanov, D. T. Borup, S. A. Johnson, J. Riley, O. Portniaguine, “3-D EM Imaging in Quasi-Static regime, of Inhomogeneities in Ocean Sediment with Layered Green’s Functions: Experiment and Theory”, Second International Symposium on Three- Dimensional Electromagnetics, University of Utah, Salt Lake City, U.S.A., October 27-29, 1999.
38. Steven A. Johnson, David T. Borup, James W. Wiskin, Michael Zhdanov, O. Portniaguine, Edward Nichols, Ugo Conti and Giuseppe Guarino .”Construction of CPT Hardware and Software for 3-D, EM Imaging of DNAPL by Quasi-Static Regime Methods”, Second International Symposium on Three-Dimensional Electromagnetics, University of Utah, Salt Lake City, U.S.A., October 27-29, 1999
39. Johnson, S. A., D. T. Borup, J W. Wiskin, M. J. Berggren, T. Guillerm, and S C. Olsen, “Fast, non-perturbative, transmission inverse scattering, quantitative imaging with laboratory and simulated acoustic data”, Invited lecture at 139th Meeting of the Acoustical Society of America, May, 2000.
40. (ABSTRACT FOR INVITED TALK) S.A. Johnson, D.T. Borup, J.W. Wiskin, M.J. Berggren, T. Guillerum,:and S.C. Olsen. “Fast, nonperturbative, transmission inverse scattering, quantitative imaging with laboratory and simualt4dacoutic data”. Acoustical Soc. of Amer., 139th Meeting, 31 May 2000, Weston Peachtree Plaza, Atlanta, GA.
41. Wiskin, J. W,, Johnson, SA, Borup, DT., “Wave Propagation and Nonlinear Inversion in Layered or Moving Media – Fast Algorithms for High Contrasts,” Soc. Indust. Appl. Math. (SIAM) Annual Meeting, Proceedings, San Diego, California, July 9-13, 2001.
42. Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M. Berggren, “Noninvasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation: In Vivo Validation”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005.
43. Johnson, S., D. T. Borup, J. W. Wiskin, Included section in Revision of ‘Image Reconstruction from Projections: The Fundamentals of Computerized Tomography’, Gabor T. Herman, Academic Press, New York, 2005.
44. Wiskin, JW, DT Borup, SA Johnson, M Berggren, T. Abbott, R. Hanover, “Full Wave Nonlinear Inverse Scattering: High Resolution Quantitative Breast Tissue Tomography”, Invited Talk at the 28th Acoustical Imaging Symposium in San Diego, California, March 20- 23, 2005.
45. Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M Berggren, M Kammeyer, Scott Olsen, Jeff Pattee, F. Setinsek, K. Stewart, B. Hanover, “Design and first Clinical Implementation of the Ultrasound CT™ System for Breast Imaging”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005.
46. Wiskin, JW, Borup, DT, Johnson, SA, Berggren, M., Hanover, B., Setinsek, F., Hanover, R., Acoustic Inverse Scattering in Breast Imaging, 1st Annual Mountain West Biomedical Engineering Conference, Snowbird Cliff Lodge, Snowbird, Utah, Sept. 16-17th, 2005.
47. Steven A. Johnson, Robert Bell, Michael Berggren, David Borup, Barry Hanover, Rita Hanover, Martin Kammeyer, Scott Olsen, Jeffrey Pattee, David Robinson, Frank Setinsek, Kortlan Stewart, and James Wiskin. “DESIGN AND FIRST CLINICAL IMPLEMENTATION OF AN ULTRASOUND-CTTM SYSTEM FOR BREAST IMAGING”. 28th International Acoustical Imaging Symposium, San Diego, CA, USA, March 20-23, 2005. Plenum/Kluwer, Dordrecht, Netherlands. (written but not submitted).
48. Steven A. Johnson, Thomas Abbott, Robert Bell, Michael Berggren, David Borup, David Robinson, James Wiskin, Scott Olsen and Barry Hanover. “NONINVASIVE BREAST TISSUE CHARACTERIZATION USING ULTRASOUND ATTENUATION: IN VIVO VALIDATION”. 28th International Acoustical Imaging Symposium, San Diego, CA, USA, March 20-23, 2005. Plenum/Kluwer, Dordrecht, Netherlands.
49. J Wiskin, D.T. Borup, S.A. Johnson, M. Berggren , T. Abbott, R. Hanover. “FULL WAVE, NON-LINEAR, INVERSE SCATTERING: HIGH RESOLUTION QUANTITATIVE BREAST TISSUE TOMOGRAPHY”. 28th International Acoustical Imaging Symposium, San Diego, CA, USA, March 20-23, 2005. Plenum/Kluwer, Dordrecht, Netherlands.
50. Johnson, S.A., D.T Borup, J.W. Wiskin, M.J. Berggren, B. Hanover, F. Setinsek,, S.C. Olsen, K. Callahan, and staff. “From laboratory to clinical trails; an odyssey of ultrasound inverse scattering imaging for breast cancer diagnosis”, invited, 4th Joint meeting of the Acoustical Society of America and the Acoustical Society of Japan., 28 Nov.–02 Dec. 2006, Sheraton Waikiki Hotel, Honolulu, Hawaii.. Special session on: BIOMEDICAL ULTRASOUND/BIORESPONSE TO VIBRATION: (BB), Acoustic tomography in tissue., Nov. 2006.
51. Wiskin, J., D. Borup, S. Johnson, M. Berggren, B. Hanover, S. Olsen, F. Setinsek, R. Hanover, and TSI staff, Full wave nonlinear inverse scattering for transmission breast imaging, 4th JOINT MEETING OF THE ACOUSTICAL SOCIETY OF AMERICA AND THE ACOUSTICAL SOCIETY OF JAPAN 28, Special session on: BIOMEDICAL ULTRASOUND/BIORESPONSE TO VIBRATION: (BB), Acoustic tomography in tissue., Nov. 2006.
52. Andre, M.P. , C. Barker, N. Sekhon, L.K. Olson, D. Borup and J. Wiskin, Recent experience with ultrasound computed tomography for breast imaging, (invited), 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA., 2007.
53. Wiskin, J. D. T. Borup, S.A. Johnson, M. Berggren, T. Abbott, R. Hanover, “Full-Wave, Non-linear, Inverse Scattering,” Acoustical Imaging, Vol. 28, p183-193,. M. Andre, editor, Springer, 2007
54. Johnson, S. T. Abbott, R. Bell, M Berggren, D. Borup, D. Robinson, J. Wiskin, S. Olsen, B. Hanover, “Non-Invasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation,” , Acoustical Imaging, Vol. 28, p147-154, M. Andre, editor, Springer, 2007
55. Wiskin, J., D. Borup, S. A. Johnson, M. Berggren, F. Setinsek, B. Hanover, S. Olsen and K. Callahan, Multi-frequency, fully nonlinear, acoustic inverse scattering: theory and breast tissue characterization, 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA. 2007.
56. Callahan, K.S., J.W. Wiskin, D.T. Borup, B. Hanover, S.A. Johnson and Y.R. Parisky, Representative patient case studies of speed of sound and attenuation of sound images from trans mission ultra sound imaging of the breast, 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA. , 2007
57. Callahan, KS, DT Borup, SA Johnson, J Wiskin, Y Parisky, Transmission breast ultrasound Imaging representative case studies of speed of sound and attenuation of sound computed tomographic Images., 17th Annual National Interdisciplinary Breast Conference, Las Vegas, NV., Mar. 2007, Am Journ Clin Oncology
58. NONINVASIVE BREAST TISSUE CHARACTERIZATION USING ULTRASOUND SPEED AND ATTENUATION: IN VIVO VALIDATION. Steven A. Johnson, Thomas Abbott, Robert Bell, Michael Berggren, David Borup, David Robinson, James Wiskin, Scott Olsen and Barry Hanover. Acoustic Imaging (Text) 2007 Springer Verlag
59. Andre, M.P. , C. Barker, N. Sekhon, L.K. Olson, D. Borup and J. Wiskin, Recent experience with ultrasound computed tomography for breast imaging, (invited), 32nd International Symposium on Ultrasonic Imaging and Tissue Characterization, May 16-18, Arlington, VA., 2007.
60. Wiskin, J. D Borup, M Andre, S Johnson, B Hanover, K Callahan, F Setinsek, C Barker, S Olsen, M Berggren, Performance of an Automated Whole-Breast Ultrasound Imaging System Employing Full-Wave 3D Inverse-Scattering, RSNA 2008, Nov. 6, 2008
61. Wiskin, J., 3-D Imaging Molecular Diagnostics: Inverse Scattering Algorithms, James Wiskin, Ph.D., Invited talk at the AACC sponsored 40th Annual Oak Ridge Conference – Breakthrough Technologies for Clinical Diagnostics , The Fairmont, San José, CA., American Assoc. of Clinical Chemists, San Jose California, April 17 – 18, 2008.
62. M.P. Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, Springer, Dordrecht, 2009.
63. Wiskin, J., D. Borup, S. Johnson, “Inverse Scattering, Theory”, Acoustical Imaging, 30, Monterey, Calif., 2009.
64. Wiskin, J., D. Borup, K. Callahan, Y. Parisky, J. Smith, M. Andre, S. Johnson, “Inverse Scattering, Results”, Acoustical Imaging 30, Monterey, Calif., 2009.
65. J. Wiskin; D. Borup; S. Johnson; M. Berggren; D. Robinson; J. Smith; J. Chen; Y. Parisky; John Klock, ‘Inverse scattering and refraction corrected reflection for breast cancer imaging’, Jan D’hooge; Stephen A. McAleavey, Eds., Proc. SPIE, 7629, 2010
66. Wiskin, JW, Borup, D., Johnson, SJ, Berggren, M., Smith, J. Callahan, K., ‘Quantitative Ultrasound Inverse Scattering and Tomographic Refraction Corrected B-Scan, American Institute of Ultrasound in Medicine (AIUM), March 27, 2010.
67. Borup, D., Wiskin, JW, Pelligretti, P., Brusaca, M., Hanover, B., Johnson, Berggren, Klock, J, ‘360 Degree Compounded, Refraction Corrected Reflection Images of Human Breast’, American Institute of Ultrasound in Medicine (AIUM), March 26, 2010.
68. M.P. Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, Springer, Dordrecht, 2009.
69. J. Wiskin; D. Borup; S. Johnson; M. Berggren; D. Robinson; J. Smith; J. Chen; Y. Parisky; John Klock, ‘Inverse scattering and refraction corrected reflection for breast cancer imaging’, Jan D’hooge; Stephen A. McAleavey, Eds., Proc. SPIE, 7629, 2010
70. J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, Inverse scattering Results, Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.
71. J. Wiskin, D. Borup, S. Johnson, Inverse scattering: Theory, Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.
72. Pellegretti, P, S Dellepiane, M. Vicari, M. Zani, M. Weigel, D. Borup, J. Wiskin, U. Saueressig, E. Kotter, and M. Langer A Clinical Experience of a Prototype Automated Breast Ultrasound System Combining Transmission and Reflection 3D Imaging, UFFC 2011-IEEE International Ultasonics Symposium Oct. 18-21, 2011, Session P3Ab, b Tomography.
73. Wiskin, JW, D Borup, M Andre, H Ojeda-Fournier, L Olson, D Robinson, S Johnson, “Quantitative Imaging via Inverse Scattering”, AAPM-COMP 2011, Ultrasound Scientific Session: Quantitative Imaging: TU-A-220-1, Moderators: J. Fowlkes M. Kolios
74. Wiskin, JW, D Borup, M Andre, L Olson, H Ojeda-Fournier, D Robinson, S Johnson, “3D Inverse Scattering and Refraction Corrected Reflection” AAPM-COMP 2011, Ultrasound Imaging Symposium – Advanced Clinical Systems Session TU-B-220-4
75. Andre, M. PhD, James Wiskin, PhD, Haydee Ojeda-Fournier, MD, Linda Olson, MD, David Borup, PhD, Melissa Ledgerwood, B.S., Steven Johnson, PhD, “Quantitative 3D Whole Breast Imaging with Transmission and Reflection Ultrasound” AAPM Ultrasound Imaging Symposium Breast Imaging and Guidance of Interventions
76. J. Wiskin, D. Borup, S. Johnson, Inverse scattering: Theory, Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.
77. J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, Inverse scattering Results, Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.
78. Vicari M, Saueressig U., Wiskin, J. Pellegretti, P., Zani, M., Ivanovas, V., Windfuhr-Blum, M., Kroschel, J., Kotter E., and Langer, M., Automated Breast Ultrasound: MRI and Ultrasound CT Imaging Similarities, 19th Annual Meeting: International Society for Magnetic Resonance in Medicine, Palais des congres de Montreal, Montreal, Quebec, Canada, 2011
79. Andre, M, J. Wiskin et al., AIUM Annual Convention, New York, 2011, “Quantitative 3- Dimensional Whole-Breast Imaging With Transmission and Reflection Ultrasound”, Advanced Breast Imaging Symposium, Moderators: M. Andre and P. Carson, Ph.D.
80. J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, Inverse scattering Results, Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.
81. J. Wiskin, D. Borup, S. Johnson, Inverse scattering: Theory, Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.
82. J. Wiskin, D. Borup, S. Johnson, M. Berggren, Non-linear inverse scattering: High resolution quantitative breast tissue tomography, J. Acoust. Soc. Am. 131, 3802 (2012); http://dx.doi.org/10.1121/1.3699240, (also in Vir. J. Bio. Phys. Res., Vol. 23, (10), Instrumentation and Development)
83. M André, J Wiskin, D. Borup, S. Johnson, H Ojeda-Fournier and L Olson, Quantitative Volumetric Breast Imaging with 3D Inverse Scatter Computed Tomography, Proceedings, Eng. Med. Biol. Soc. Conf., EMBC 12, San Diego, California, Aug. 28 – Sept. 1, 2012, peer reviewed Invited paper.
84. M André, J Wiskin, D. Borup, S. Johnson, H Ojeda-Fournier and L Olson, Quantitative Volumetric Breast Imaging with 3D Inverse Scatter Computed Tomography, Proceedings, Eng. Med. Biol. Soc. Conf., EMBC 12, San Diego, California, Aug. 28 – Sept. 1, 2012, peer reviewed Invited paper.
85. M André, J Wiskin, D. Borup, S. Johnson, H Ojeda-Fournier and L Olson, Quantitative Volumetric Breast Imaging with 3D Inverse Scatter Computed Tomography, Proceedings, Eng. Med. Biol. Soc. Conf., EMBC 12, San Diego, California, Aug. 28 – Sept. 1, 2012, peer reviewed Invited paper.
86. J. Wiskin, D. Borup, S. Johnson, M. Berggren, Non-linear inverse scattering: High resolution quantitative breast tissue tomography, J. Acoust. Soc. Am. 131, 3802 (2012); http://dx.doi.org/10.1121/1.3699240, (also in Vir. J. Bio. Phys. Res., Vol. 23, (10), Instrumentation and Development)
87. QTUS – Quantitative Transmission Ultrasound Volumetric Reflection Tomography. J. Wiskin, D. Borup, E. Iuanow, M. Lenox, J. Klock. Journal of the Acoustical Society of America 2014
88. GPU Accelerated Transmission Image Reconstruction for 3D Quantitative Ultrasound Breast Imaging. Qun(Maxine) Liu, Jim Hardwick, Dave Borup, Ph.D., Jim Wiskin, Ph.D. Nvidia Conference 2014
89. Mark W. Lenox, James Wiskin, Matthew A. Lewis, Stephen Darrouzet, David Borup, and Scott Hsieh. Imaging Performance of Quantitative Transmission Ultrasound; Hindawi Publishing Corporation International Journal of Biomedical Imaging vol. 2015; Article ID 454028. doi:10.1155/2015/454028
90. John C. Klock, Elaine Iuanow, BilalMalik, Nancy A. Obuchowski, JamesWiskin, and Mark Lenox. Anatomy-Correlated Breast Imaging and Visual Grading Analysis Using Quantitative Transmission Ultrasound. International Journal of Biomedical Imaging Volume 2016, Article ID 7570406, 9 pages http://dx.doi.org/10.1155/2016/7570406
91. Malik, B. et al. Objective breast tissue image classification using Quantitative Transmission ultrasound tomography. Nature Sci. Rep. 6, 38857; doi: 10.1038/srep38857 (2016).
92. Elaine Iuanow, MD, Kathleen Smith, MBA, Nancy A. Obuchowski PhD†, Jennifer Bullen MS† and John C. Klock, MD. Accuracy of Cyst vs. Solid Diagnosis in the Breast Using Quantitative Transmission (QT) Ultrasound. Academic Radiology 2017 Vol 24:1148-1153; doi: 10.1016/j.acra.2017.03.024. Epub 2017 May 23; PubMed ID 28549870. Academic Radiology has posted the study in full for free. http://www.healthimaging.com/topics/womens-health/breast-imaging/and-coming-ultrasound-technology-shows-prowess-mammography-adjunct.
93. John C Klock, Elaine Iuanow, Kathleen Smith, Nancy A and Obuchowski Visual Grading Assessment of Quantitative Transmission Ultrasound Compared to Digital X-ray Mammography and Hand-held Ultrasound in Identifying Ten Breast Anatomical Structures. BAOJ Clinical Trials 3: 015. (2017)
94. J. W. Wiskin, D. T. Borup, E. Iuanow, J. Klock, and M. W. Lenox; 3-D Nonlinear Acoustic Inverse Scattering: Algorithm and Quantitative Results; IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL In Press 2018
95. Bilal Malik, Robin Terry, James Wiskin, Mark Lenox; Quantitative transmission ultrasound tomography: Imaging and performance characteristics. Medical Physics. (2018). Click here to read the research paper
96. Bilal H. Malik, PhD, John C. Klock, MD; Breast Cyst Fluid Analysis Correlations with Speed of Sound Using Transmission Ultrasound. Academic Radiology. (2018). Click here to read the research paper
97. Rajni Natesan, Bilal Malik, Lauralyn R. Markle, Vashita Dhir, Robin Terry; Accuracy of Volumetric Measurements in the Breast: A Study of Comparing Ultrasound Tomography and Hand-Held Ultrasound. (2018). Click here to read the abstract.
98. Bilal Malik, Austin Todd, Alyson Terry, Farzad Fereidouni, Rajni Natesan, John Klock, James Wiskin, Mark Lenox, Richard Levenson; Radiologic-pathologic Validation of Transmission Ultrasound Tomography Using Microscopy with UV Surface Excitation (March 2019) Study available here.
99. James Wiskin, Bilal Malik, Rajni Natesan, Nasser Pirshafiey, John Klock, Mark Lenox; Transmission Ultrasound Imaging of the Human Knee. James W. Wiskin, Bilal Malik, Rajni Natesan, Nasser Pirshafiey, John Klock, and Mark Lenox “3D full inverse scattering ultrasound tomography of the human knee (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 109550K (15 March 2019); doi: 10.1117/12.2512595 Study available for download here.
100. Mark Lenox, John Klock, Cathy Ruoff, Nasser Pirshaifey, Robin Terry, Bilal Malik, and James Wiskin “3D inverse scattering in wholebody ultrasound applications (Conference Presentation)”, Proc. SPIE 10955, Medical Imaging 2019: Ultrasonic Imaging and Tomography, 1095511 (15 March 2019); doi: 10.1117/12.2512575. Study available here.
101. James Wiskin, Bilal Malik, Rajni Natesan, Mark Lenox “Quantitative Assessment of Breast Density Using Transmission Ultrasound Tomography” (20 March 2019) Click here to read the published research.
102. Bilal Malik, Rajni Natesan, Sanghyeb Lee, James Wiskin; AI-based Quantitative Breast Density Assessment Using Transmission Ultrasound. (16 June 2019). Click here to view the presentation.
103. Bilal Malik, Sanghyeb Lee, James Wiskin, Rajni Natesan; Application of Machine Learning in the Calculation of Breast Density Using Transmission Ultrasound: A Comparison with Automated Mammographic Assessment. (2019). View Abstract
104. Bilal Malik, Nasser Pirshafiey, John C. Klock, Rajni Natesan; 3D Printing of Whole Breast and Individual Breast Tissue Types based on Transmission Ultrasound. (2019) View Abstract
105. Rajni Natesan, Sanghyeb Lee, Diane Navarro, Christopher Anaje, Bilal Malik; Radiomics in Transmission Ultrasound Improve Differentiation between Benign and Malignant Breast Masses. (2019). View Abstract
106. James W. Wiskin, Rajni Natesan, Sam Lee, Bilal Malik; Quantitative Breast Density (QBD) estimation with 3D transmission ultrasound and incomplete information. (2020). View Abstract
107. Bilal H. Malik, Sanghyeb Lee, Rajni Natesan, James W. Wiskin; Clustering-based quantitative breast density assessment using 3D transmission ultrasound. (2020). View Abstract
108. James W. Wiskin, Bilal Malik, Mark Lenox, Nasser Pirshafiey, Rajni Natesan, John Klock; Limited view reconstructions with 3D transmission ultrasound tomography: clinical implications and quantitative accuracy. (2020). View Abstract
109. James W. Wiskin, Bilal Malik, Veena Theendakara, Rajni Natesan, John Klock; Orthopedic and myopathic imaging with 3D transmission ultrasound tomography: experimental verification, quantitative accuracy and clinical implications. (2020). View Abstract